Cancer Pathobiology, Tumorigenesis, and Cancer Prevention and Treatment

Figure of cilium and basal bodyCancer is a complex disease. The ability of cancers to develop has been attributed to a set of cancer hallmarks including: unlimited growth (proliferation, immortality, reprogrammed metabolism), resistance to cell death (apoptosis), development of a blood supply (angiogenesis), evasion of the body’s immune system (immunosuppression) and the ability to leave the primary tumor site and grow in other organs (invasion and metastasis). These cellular phenotypes are generated at least in part by the cancer cells ability to adapt and change its genetic profile (genomic instability) and to adapt to and exploit the location where it develops (tumor microenvironment). Division of Translational and Regenerative Medicine scientists continue to work towards understanding these hallmarks of cancer to further clarify the mechanisms that contribute to this complex disease. As our research progresses and we better understand what is critical for a cancer cell to function and live, we are motivated to utilize our discoveries to develop novel therapeutic strategies.