Jason X.-J. Yuan, MD, PhD

  • Professor, Medicine
  • Professor, Physiology
  • Chief, Division of Translational and Regenerative Medicine
  • Associate Vice President for Translational Health Sciences, UA Health Sciences

As associate vice president for translational health sciences, Dr. Jason X.-J. Yuan is responsible for leading the development of impactful and sustainable translational health strategies. He also oversees efforts to improve and expedite the conduct of AHSC research and create nurturing research environments for training physician-scientists.
Dr. Yuan is also on faculty at the College of Medicine – Tucson as a professor of medicine, with a joint appointment as professor of physiology.
Dr. Yuan has previously held appointments as professor of medicine and pharmacology, vice chair for scholarly activities for the Department of Medicine, director of the Pulmonary Hypertension Translational Research Program in the Institute for Personalized Respiratory Medicine, and director of the Program in Pulmonary Vascular Disease and Right Heart Function in the Center for Cardiovascular Research at the University of Illinois at Chicago. He also has held faculty positions in the Department of Medicine, School of Medicine, University of California, San Diego, and the Department of Physiology, University of Maryland School of Medicine, Baltimore.

Research Interests: 

As a physician-scientist, Dr. Yuan’s research interests include pulmonary vascular pathophysiology and pathogenic mechanisms of pulmonary vascular disease, including idiopathic pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis, obstructive sleep apnea, sickle cell disease and scleroderma.

Degrees
  • MD: Suzhou Medical College, Suzhou, China, 1983
  • PhD: Peking Union Medical College, Beijing, China, 1993
Honors and Awards
  • Established Investigator Award, American Heart Association
  • Pulmonary Vascular Research Institute Achievement Award
  • Guggenheim Fellowship Award, 2008
  • Patent co-holder, “Regulating Expression of Transient Receptor Potential Channel Genes,” with C.V. Remillard, L.J. Rubin and Y. Yu
  • Member, American Thoracic Society, 1989
  • Fellow, American Physiological Society, 1989
  • Fellow, American Association for the Advancement of Science, 1993
  • Fellow, American Heart Association, 2003
  • Elected Member, American Society for Clinical Investigation, 2007
  • Elected Member, Association of American Physicians, 2013
Internship
  • Suzhuo Medical College Hospital and Suzhou Third City Hospital
Fellowship
  • University of Maryland School of Medicine, Departments of Physiology and Medicine, Baltimore, MD, 1988-1991

Select Publications

2017

Wang, T., C. Gross, A. A. Desai, E. Zemskov, X. Wu, A. N. Garcia, J. R. Jacobson, J. X. - J. Yuan, J. G. N. Garcia, and S. M. Black, "Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 4, pp. L452-L476, 2017 Apr 01. PMID: 27979857
Song, S., R. J. Ayon, A. Yamamura, H. Yamamura, S. Dash, A. Babicheva, H. Tang, X. Sun, A. G. Cordery, Z. Khalpey, et al., "Capsaicin-induced Ca(2+) signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L309-L325, 2017 Mar 01. PMID: 27979859
Chen, J., J. R. Sysol, S. Singla, S. Zhao, A. Yamamura, D. Valdez-Jasso, T. Abbasi, K. M. Shioura, S. Sahni, V. Reddy, et al., "Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension.", Circulation, 2017 Feb 15. PMID: 28202489
Kumar, iv, S., X. Sun, S. Kumar Noonepalle, Q. Lu, E. Zemskov, T. Wang, S. Aggarwal, C. Gross, S. Sharma, A. A. Desai, et al., "Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.", Free Radic Biol Med, vol. 102, pp. 217-228, 2017 Jan. PMID: 27838434

2016

Smith, K. A., R. J. Ayon, H. Tang, A. Makino, and J. X. - J. Yuan, "Calcium-Sensing Receptor Regulates Cytosolic [Ca (2+) ] and Plays a Major Role in the Development of Pulmonary Hypertension.", Front Physiol, vol. 7, pp. 517, 2016. PMCID: PMC5095111  PMID: 27867361