Joe G. N. "Skip" Garcia, MD

  • UA Senior Vice President for Health Sciences
  • Professor, Medicine

Joe G. N. "Skip" Garcia, MD, is senior vice president for health sciences at the University of Arizona, an endowed UA professor of medicine, and an elected member of the Institute of Medicine of the National Academies. An internationally noted physician-scientist, health administrator, scholar and educator, Dr. Garcia also is a leading authority on the genetic basis of lung disease and the prevention and treatment of inflammatory lung injury.

A key member of the UA’s senior executive team, Dr. Garcia provides academic leadership for the Arizona Health Sciences Center (AHSC) colleges: the UA College of Medicine – Tucson, the UA College of Medicine – Phoenix, the UA College of Pharmacy, the UA College of Nursing and the UA Mel and Enid Zuckerman College of Public Health. He also has direct leadership oversight of the UA Cancer Center.

Before joining the UA, Dr. Garcia served as vice president for health affairs at the University of Illinois and as the Earl M. Bane Professor of Medicine, Pharmacology and Bioengineering at the University of Illinois at Chicago.  As vice president for health affairs, Dr. Garcia oversaw the University of Illinois Hospital & Health Sciences System (UI Health), a $1.2 billion health sciences and clinical enterprise. He also provided oversight of the University of Illinois Hospital and the University’s federally qualified community health centers.

His prior leadership positions include director of the Division of Pulmonary and Critical Care Medicine at Johns Hopkins University (1998-2005), chairman of the Department of Medicine at the University of Chicago (2005-2009), and vice chancellor for research at UIC (2010-2012).

Dr. Garcia is internationally recognized for his genetic-based research on lung disease and for development of novel therapies for critically ill patients with acute inflammatory lung disease. He has nearly 400 peer-reviewed publications. He has an expansive portfolio of NIH-sponsored research and continues to direct large federally funded programs.
Dr. Garcia is a passionate advocate for the training of physician-scientists and is an active supporter of minority medical and science students. He has nurtured many minority students at UIC, Johns Hopkins University and the University of Chicago, guiding them into MD and PhD programs.

Dr. Garcia earned his Bachelor of Science in biology at the University of Dallas in 1976 and received his medical degree from the University of Texas Southwestern Medical School in 1980. He completed an internship and residency in internal medicine at the University of Iowa Hospitals and Clinics (1980-1983) and completed a fellowship in pulmonary and critical care medicine at Albany Medical College (1983-1985).

Research Interests: 

The Garcia laboratory is a state of the art pulmonary research lab focusing on the genetics and proteomics of lung biology and disease. Our goal is to understand the molecular mechanisms of lung inflammatory processes, particularly those producing lung edema or vascular leak. The laboratory encompasses a mosaic of specialized talents to investigate all aspects of research including gene discovery, protein function assessment, SNP discovery, genetic manipulation, in vivo testing, and candidate gene and biomarker identification. Using this bench-to-bedside approach, we hope to translate our basic research into potential novel clinical therapies.

Degrees
  • BS: University of Dallas - Irving, 1976
  • MD: University of Texas Southwestern Medical School, 1980
Honors and Awards
  • Secretary-Treasurer, Councilor, President, Central Society for Clinical Research, 1996- 2007
  • American Society for Clinical Investigation (elected), 1996
  • Interurban Clinical Club (elected), 1999
  • David M. Levine Excellence in Mentoring Award, Johns Hopkins University, Department of Medicine, 2002
  • Distinguished Scientific Achievement Award, American Thoracic Society, 2003
  • Chair: Pulmonary Circulation Assembly (elected), American Thoracic Society, 2003-2005
  • Howard Hughes Medical Institute Scientific Review Board, 2003-2005
  • American Clinical and Climatological Society (elected), 2004
  • Gordon Research Conference, Chair (2004, 2006), Endothelial Cell Phenotypes in Health & Disease, 2004
  • Association of American Physicians (elected), 2005
  • Innovations in Diversity Award, Association of Professors in Medicine, 2009
  • National Academy of Medicine (formerly the Institute of Medicine) National Academies (elected), 2011
  • Distinguished Leadership Award, American Thoracic Society, 2015
Residency
  • University of Iowa, Internal Medicine, 1980-1983
Fellowship
  • Albany Medical College, Pulmonary and Critical Care Medicine, 1983-1984
  • Albany Medical College, Postdoc, 1994-1985

Select Publications

2017

Wang, T., C. Gross, A. A. Desai, E. Zemskov, X. Wu, A. N. Garcia, J. R. Jacobson, J. X. - J. Yuan, J. G. N. Garcia, and S. M. Black, "Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 4, pp. L452-L476, 2017 Apr 01. PMID: 27979857
Song, S., R. J. Ayon, A. Yamamura, H. Yamamura, S. Dash, A. Babicheva, H. Tang, X. Sun, A. G. Cordery, Z. Khalpey, et al., "Capsaicin-induced Ca(2+) signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L309-L325, 2017 Mar 01. PMID: 27979859
Chen, J., J. R. Sysol, S. Singla, S. Zhao, A. Yamamura, D. Valdez-Jasso, T. Abbasi, K. M. Shioura, S. Sahni, V. Reddy, et al., "Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension.", Circulation, 2017 Feb 15. PMID: 28202489
Kumar, iv, S., X. Sun, S. Kumar Noonepalle, Q. Lu, E. Zemskov, T. Wang, S. Aggarwal, C. Gross, S. Sharma, A. A. Desai, et al., "Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.", Free Radic Biol Med, vol. 102, pp. 217-228, 2017 Jan. PMID: 27838434

2016

Bime, C., T. Zhou, T. Wang, M. J. Slepian, J. G. N. Garcia, and L. Hecker, "Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis.", Pulm Circ, vol. 6, issue 2, pp. 196-201, 2016 Jun. PMCID: PMC4869924  PMID: 27252846