Yves A Lussier, MD, FAMCI

  • Director, UAHS Center for Biomedical Informatics & Biostatistics
  • Associate Director, Informatics, UA BIO5 Institute
  • Associate Vice President / Chief Knowledge Officer, UA Health Sciences
  • Professor, Medicine - (Tenure Track)
  • Professor, Statistics-GIDP

Dr. Lussier has extensive experience in advising and leading computational oncology and informatics research and service groups. He established the first university-wide biomedical informatics core services at the University of Illinois at Chicago and at the University of Arizona. Dr. Lussier is currently the chair of the National Library of Medicine Extramural Grant Review (NIH BLIRC 2014) and is the co-founder of two international conferences in translational bioinformatics (the AMIA Summit on Translational Bioinformatics and The Translational Bioinformatics Conference). He has contributed and is servicing on about thirty board of directors, as well as scientific and editorial boards inclusive of pharmaceuticals, journals, information technology startups and large corporations. Dr. Lussier is currently the Associate Director of Cancer Informatics and Health Precision Medicine at the University of Arizona Cancer Center. Directing services in clinical research informatics (CRI) and translational bioinformatics (TBI), Dr. Lussier has previously conceived, directed, hired, and managed the first TBI and CRI service cores of three NIH-funded grants and their renewal: (i) The Institute for Translational Medicine of the University of Chicago (CTSA 5UL1RR024999, Informatics Core Director jointly with JS, 2006-11), (ii) Assoc. Director for the U of Chicago Comprehensive Cancer Center (5UL1RR024999; 2006-11), and (iii) the Director of the Informatics Core of the Northeast Biodefense Center at Columbia University (5U54AI057158, 2003-6). Dr. Lussier's translational bioinformatics expertise includes his research group which has produced over 145 scientific papers and he has presented at 14 conference keynote addresses.  He has mentored or co-mentored 22 PhD candidates and 21 post-doctoral fellows, of which five obtained K-awards and two are Directors for Biomedical Informatics Departments and/or Institutes in their respective institutions (Drs. Philip Payne at Ohio State University and Neil Sarkar at Brown University).

Research Interests: 

Dr. Lussier’s research interests focus on the use of ontologies, knowledge technologies and genomic network model to accurately individualize the treatment of disease and to repurpose therapies. He has National Institutes of Health funding for a clinical trial that repositioned a combination therapy, he also bioinformatically predicted and obtained biological confirmation of several novel tumor suppressor microRNAs, including the first one underpinning the oligo- vs poly- metastasis development of cancer.

Select Publications


Li, Q., G. A Schissler, V. Gardeux, J. Berghout, I. Achour, C. Kenost, H. Li, H. Helen Zhang, and Y. A. Lussier, "kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects.", J Biomed Inform, vol. 66, pp. 32-41, 2017 Feb. PMCID: PMC5316373  PMID: 28007582
Huang, Y., S-F. Ma, M. S. Espindola, R. Vij, J. M. Oldham, G. B. Huffnagle, J. R. Erb-Downward, K. R. Flaherty, B. B. Moore, E. S. White, et al., "Microbes Associate with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.", Am J Respir Crit Care Med, 2017 Feb 03. PMID: 28157391


Grief, S. N., J. Patel, K. M. Kochendorfer, L. A. Green, Y. A. Lussier, J. Li, M. Burton, and A. D. Boyd, "Simulation of ICD-9 to ICD-10-CM Transition for Family Medicine: Simple or Convoluted?", J Am Board Fam Med, vol. 29, issue 1, pp. 29-36, 2016 Jan-Feb. PMID: 26769875
A Schissler, G., Q. Li, J. L. Chen, C. Kenost, I. Achour, D. D Billheimer, H. Li, W. W. Piegorsch, and Y. A. Lussier, "Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells.", Bioinformatics, vol. 32, issue 12, pp. i80-i89, 2016 Jun 15. PMCID: PMC4908332  PMID: 27307648
Li, H., I. Achour, L. Bastarache, J. Berghout, V. Gardeux, J. Li, Y. Lee, L. Pesce, X. Yang, K. S. Ramos, et al., "Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.", NPJ Genom Med, vol. 1, 2016. PMCID: PMC4966659  PMID: 27482468