TOPIC: "Design and Discovery of Probes and/or Potential Therapeutic Lead Compounds for Cancer, Ischemia-Reperfusion Injury, HIV/AIDS, or Mitochondrial Protection"
SPEAKER: John K. Buolamwini, PhD | Chair and Professor, Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science
Tuesday, Oct. 23, 2018
College of Pharmacy, Skaggs Building, Room 325
About Dr. John K. Buolamwini
My laboratory is involved in small molecule drug/probe design and discovery research. The talk will highlight the use of computer-aided drug design, chemical synthesis and biological studies to discover and optimize potential drug lead compounds and/or probes targeting EGFR, MDM2 and STAT3 for cancer, nucleoside transporters for ischemia–reperfusion injury and protection of mitochondrial from drug toxicity, and HIV integrase for HIV/AIDS. An interdisciplinary approach has been applied to the identification of small molecules with potential therapeutic leads and/or the development of pharmacological tools for difficult-to-treat cancers such as pancreatic cancer, triple negative breast cancer, and melanoma, as well as ischemic heart disease, HIV/AIDS, and mitochondrial rescue.
Host: Jun Wang
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University of Arizona College of Pharmacy
Skaggs Building, Room 325
1295 N Martin Ave, Tucson, AZ 85721