The following published papers illustrate the latest investigative endeavors of faculty and research staff in the University of Arizona Department of Medicine and its 14 divisions. Click the PubMed links to read on about how they're setting the pace for the future of health care and precision medicine solutions to improve patient lives in Arizona and beyond.


Gandhi, M., D. Rajagopal, S. Parthasarathy, S. Raja, S-T. Huang, and A. Senthil Kumar, "In Situ Immobilized Sesamol-Quinone/Carbon Nanoblack-Based Electrochemical Redox Platform for Efficient Bioelectrocatalytic and Immunosensor Applications.", ACS Omega, vol. 3, issue 9, pp. 10823-10835, 2018 Sep 30. PMCID: PMC6173515  PMID: 30320253
Combs, D., G. Skrepnek, M. D. Seckeler, B. J. Barber, W. J. Morgan, and S. Parthasarathy, "Sleep-Disordered Breathing is Associated With Increased Mortality in Hospitalized Infants With Congenital Heart Disease.", J Clin Sleep Med, vol. 14, issue 9, pp. 1551-1558, 2018 Sep 15. PMCID: PMC6134246  PMID: 30176962
Feemster, L. C., H. L. Saft, S. J. Bartlett, S. Parthasarathy, T. Barnes, P. Calverley, R. J Curtis, D. H. Hickam, R. A. Mularski, D. H. Au, et al., "Patient-centered Outcomes Research in Pulmonary, Critical Care, and Sleep Medicine. An Official American Thoracic Society Workshop Report.", Ann Am Thorac Soc, vol. 15, issue 9, pp. 1005-1015, 2018 Sep. PMID: 30168741
V, K. Raj, S. Sundar Rajagopalan, S. Bhardwaj, R. Panda, V. Reddy Reddam, C. Ganne, R. Kenchaiah, R. C. Mundlamuri, T. Kandavel, K. K. Majumdar, et al., "Machine learning detects EEG microstate alterations in patients living with temporal lobe epilepsy.", Seizure, vol. 61, pp. 8-13, 2018 Oct. PMID: 30044996
Sei, Y., J. Feng, L. Samsel, A. Oksuz White, X. Zhao, S. Yun, D. Citrin, J. Philip McCoy, S. Sundaresan, M. M. Hayes, et al., "Mature Enteroendocrine Cells Contributes to Basal and Pathological Stem Cell Dynamics in the Small Intestine.", Am J Physiol Gastrointest Liver Physiol, 2018 May 31. PMID: 29848020
De la Torre, Y. Sanchez-, R. Wadeea, V. Rosas, and K. L. Herbst, "Lipedema: friend and foe.", Horm Mol Biol Clin Investig, vol. 33, issue 1, 2018 Mar 09. PMCID: PMC5935449  PMID: 29522416
Bailey, O., S. Parthasarathy, and D. Combs, "Too Little, but Still Great?", J Clin Sleep Med, vol. 14, issue 6, pp. 907-908, 2018 Jun 15. PMCID: PMC5991944  PMID: 29852920
Ghazala, S., J. Bilal, E. Ross, I. Bin Riaz, B. Kalb, and K. L. Herbst, "Low-Dose d-Amphetamine Induced Regression of Liver Fat Deposits in Dercum Disease.", Am J Med, vol. 131, issue 6, pp. 705-708, 2018 Jun. PMID: 29355511
Arora, N. K., M. K. C. Nair, S. Gulati, V. Deshmukh, A. Mohapatra, D. Mishra, V. Patel, R. M. Pandey, B. C. Das, G. Divan, et al., "Neurodevelopmental disorders in children aged 2-9 years: Population-based burden estimates across five regions in India.", PLoS Med, vol. 15, issue 7, pp. e1002615, 2018 Jul. PMCID: PMC6057634  PMID: 30040859
Wang, H., A. Rodriguez-Pla, and A. Campagna, "Rapid and life-threatening heart failure induced by pazopanib.", BMJ Case Rep, vol. 2018, 2018 Aug 16. PMCID: PMC6101341  PMID: 30115717
Parthasarathy, S., D. Combs, S. N. Patel, C. Poongkunran, and S. F. Quan, "Provider Types and Outcomes in Obstructive Sleep Apnea Case Finding and Treatment.", Ann Intern Med, vol. 169, issue 3, pp. 201-202, 2018 Aug 07. PMID: 30083707
Shubitz, L. F., D. A. Powell, H. T. Trinh, L. M Lewis, M. J. Orbach, J. A. Frelinger, and J. N. Galgiani, "Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.", Vaccine, 2018 Apr 30. PMID: 29724507
Wang, Z., R. Ocadiz-Ruiz, S. Sundaresan, L. Ding, M. Hayes, N. Sahoo, H. Xu, and J. L. Merchant, "Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse.", J Vis Exp, issue 138, 2018 08 15. PMCID: PMC6126789  PMID: 30175991
Razumilava, N., D. L. Gumucio, L. C. Samuelson, Y. M. Shah, A. Nusrat, and J. L. Merchant, "Indian Hedgehog Suppresses Intestinal Inflammation.", Cell Mol Gastroenterol Hepatol, vol. 5, issue 1, pp. 63-64, 2018. PMCID: PMC5736880  PMID: 29276751
Robbins, R., A. Seixas, G. Jean-Louis, S. Parthasarathy, D. M. Rapoport, G. Ogedegbe, and J. A. Ladapo, "National patterns of physician management of sleep apnea and treatment among patients with hypertension.", PLoS One, vol. 13, issue 5, pp. e0196981, 2018. PMCID: PMC5965818  PMID: 29791455
Merchant, J. L., "Parietal Cell Death by Cytokines.", Cell Mol Gastroenterol Hepatol, vol. 5, issue 4, pp. 636-637, 2018. PMCID: PMC5924744  PMID: 29713663


Herbst, K. L., C. Ussery, and A. Eekema, "Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema.", Horm Mol Biol Clin Investig, vol. 33, issue 2, 2017 Sep 20. PMID: 28930626
Kruse, R., J. Krantz, N. Barker, R. L. Coletta, R. Rafikov, M. Luo, K. Højlund, L. J. Mandarino, and P. R. Langlais, "Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.", Mol Cell Proteomics, vol. 16, issue 10, pp. 1718-1735, 2017 Oct. PMCID: PMC5629260  PMID: 28550165
Indik, J. H., K. K. Patton, M. Beardsall, C. A. Chen-Scarabelli, M. I. Cohen, T-M. L. Dickfeld, D. E. Haines, R. H. Helm, K. Krishnan, J. Cosedis Nielsen, et al., "HRS Clinical Document Development Methodology Manual and Policies: Executive summary.", Heart Rhythm, vol. 14, issue 10, pp. e495-e500, 2017 Oct. PMID: 28965612
Tracy, C. M., G. H. Crossley, J. T Bunch, G. V. Chow, A. Leiserowitz, J. H. Indik, F. Kusumoto, L. A. Mendes, T. M. Munger, S. Murali, et al., "2017 ACC/HRS Lifelong Learning Statement for Clinical Cardiac Electrophysiology Specialists: A Report of the ACC Competency Management Committee.", J Am Coll Cardiol, 2017 Nov 15. PMID: 29191467
Ocadiz-Ruiz, R., A. L. Photenhauer, M. M. Hayes, L. Ding, E. R. Fearon, and J. L. Merchant, "ZBP-89 function in colonic stem cells and during butyrate-induced senescence.", Oncotarget, vol. 8, issue 55, pp. 94330-94344, 2017 Nov 07. PMCID: PMC5706877  PMID: 29212231
Vaughn, A. R., P. Tannhauser, R. K. Sivamani, and V. Y. Shi, "Mother Nature in Eczema: Maternal Factors Influencing Atopic Dermatitis.", Pediatr Dermatol, vol. 34, issue 3, pp. 240-246, 2017 May. PMID: 28523877
Ding, Q., I. Subramanian, T. R. Luckhardt, P. Che, M. Waghray, X. Zhao, N. Bone, A. R. Kurundkar, L. Hecker, M. Hu, et al., "Focal Adhesion Kinase Signaling Determines the Fate of Lung Epithelial Cells in Response to TGF-β.", Am J Physiol Lung Cell Mol Physiol, pp. ajplung.00121.2016, 2017 Mar 30. PMID: 28360109
Bauman, J. E., U. Duvvuri, W. E. Gooding, T. J. Rath, N. D. Gross, J. Song, A. Jimeno, W. G. Yarbrough, F. M. Johnson, L. Wang, et al., "Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer.", JCI Insight, vol. 2, issue 6, pp. e90449, 2017 Mar 23. PMCID: PMC5358497  PMID: 28352657
Palumbo, S., Y-J. Shin, K. Ahmad, A. A. Desai, H. Quijada, M. Mohamed, A. Knox, S. Sammani, B. A. Colson, T. Wang, et al., "Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L297-L308, 2017 Mar 01. PMID: 28062482
Song, S., R. J. Ayon, A. Yamamura, H. Yamamura, S. Dash, A. Babicheva, H. Tang, X. Sun, A. G. Cordery, Z. Khalpey, et al., "Capsaicin-induced Ca(2+) signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L309-L325, 2017 Mar 01. PMID: 27979859
Katial, R. K., G. W. Bensch, W. W. Busse, B. E. Chipps, J. L. Denson, A. N. Gerber, J. S. Jacobs, M. Kraft, R. J. Martin, P. Nair, et al., "Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies.", J Allergy Clin Immunol Pract, vol. 5, issue 2S, pp. S1-S14, 2017 Mar - Apr. PMID: 28143691
Zhang, Y., L. Wang, Y. Zi, L. Zhang, Y. Guo, and Y. Huang, "Oridonin effectively reverses the drug resistance of cisplatin involving induction of cell apoptosis and inhibition of MMP expression in human acute myeloid leukemia cells.", Saudi J Biol Sci, vol. 24, issue 3, pp. 678-686, 2017 Mar. PMCID: PMC5372424  PMID: 28386196
Joseph, B., T. Orouji Jokar, A. Hassan, A. Azim, M. Jane Mohler, N. Kulvatunyou, S. Siddiqi, H. Phelan, M. Fain, and P. Rhee, "Redefining the association between old age and poor outcomes after trauma: The impact of frailty syndrome.", J Trauma Acute Care Surg, vol. 82, issue 3, pp. 575-581, 2017 Mar. PMID: 28225741
Addison, K. J., J. Morse, A. Robichaud, M. O. Daines, and J. G. Ledford, "A Novel in vivo System to Test Bronchodilators.", J Infect Pulm Dis, vol. 3, issue 1, 2017 Mar. PMID: 28367537
Trusler, A. R., A. K. Clark, R. K. Sivamani, and V. Y. Shi, "The Endocannabinoid System and Its Role in Eczematous Dermatoses.", Dermatitis, vol. 28, issue 1, pp. 22-32, 2017 Jan/Feb. PMID: 28098721
Tey, K. Rou, A. Aggarwal, and B. Banerjee, "Migrating coil.", BMJ Case Rep, vol. 2017, 2017 Jan 27. PMID: 28130285
Kumar, iv, S., X. Sun, S. Kumar Noonepalle, Q. Lu, E. Zemskov, T. Wang, S. Aggarwal, C. Gross, S. Sharma, A. A. Desai, et al., "Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.", Free Radic Biol Med, vol. 102, pp. 217-228, 2017 Jan. PMID: 27838434
Chen, J., J. R. Sysol, S. Singla, S. Zhao, A. Yamamura, D. Valdez-Jasso, T. Abbasi, K. M. Shioura, S. Sahni, V. Reddy, et al., "Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension.", Circulation, 2017 Feb 15. PMID: 28202489
Huang, Y., S-F. Ma, M. S. Espindola, R. Vij, J. M. Oldham, G. B. Huffnagle, J. R. Erb-Downward, K. R. Flaherty, B. B. Moore, E. S. White, et al., "Microbes Associate with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.", Am J Respir Crit Care Med, 2017 Feb 03. PMID: 28157391
Su, X., X. Qiao, J. Li, L. Gao, C. Wang, and L. Wang, "Papulonodular mucinosis, Guillain-Barré syndrome and nephrotic syndrome in a patient with systemic lupus erythematosus: a case report.", BMC Nephrol, vol. 18, issue 1, pp. 43, 2017 Feb 01. PMCID: PMC5286654  PMID: 28143420
Li, Q., G. A Schissler, V. Gardeux, J. Berghout, I. Achour, C. Kenost, H. Li, H. Helen Zhang, and Y. A. Lussier, "kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects.", J Biomed Inform, vol. 66, pp. 32-41, 2017 Feb. PMCID: PMC5316373  PMID: 28007582
Ebner, L., M. He, R. S. Virgincar, T. Heacock, S. S. Kaushik, M. S. Freemann, P. H McAdams, M. Kraft, and B. Driehuys, "Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests.", Invest Radiol, vol. 52, issue 2, pp. 120-127, 2017 Feb. PMID: 27662575
Infante, J. R., A. Patnaik, C. F. Verschraegen, A. J. Olszanski, M. Shaheen, H. A. Burris, A. W. Tolcher, K. P. Papadopoulos, M. Beeram, S. M. Hynes, et al., "Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer.", Cancer Chemother Pharmacol, vol. 79, issue 2, pp. 315-326, 2017 Feb. PMID: 28097385
Kartan, S., V. Y. Shi, A. K. Clark, and L. S. Chan, "Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.", Am J Clin Dermatol, vol. 18, issue 1, pp. 105-126, 2017 Feb. PMID: 27878477
Odio, C. D., B. E. Marciano, J. N. Galgiani, and S. M. Holland, "Risk Factors for Disseminated Coccidioidomycosis, United States.", Emerg Infect Dis, vol. 23, issue 2, 2017 Feb. PMCID: PMC5324825  PMID: 28098554
Derkac, W. M., J. R. Finkelmeier, D. J. Horgan, and M. D. Hutchinson, "Diagnostic yield of asymptomatic arrhythmias detected by mobile cardiac outpatient telemetry and autotrigger looping event cardiac monitors.", J Cardiovasc Electrophysiol, vol. 28, issue 12, pp. 1475-1478, 2017 Dec. PMID: 28940881
Kalb, B., J. H. Indik, P. Ott, and D. R. Martin, "MRI of patients with implanted cardiac devices.", J Magn Reson Imaging, 2017 Aug 04. PMID: 28776823
Liang, J. J., B. P. Betensky, D. Muser, E. S. Zado, E. Anter, N. D. Desai, D. J. Callans, R. Deo, D. S. Frankel, M. D. Hutchinson, et al., "Long-term outcome of surgical cryoablation for refractory ventricular tachycardia in patients with non-ischemic cardiomyopathy.", Europace, 2017 Apr 10. PMID: 28402404
Wang, T., C. Gross, A. A. Desai, E. Zemskov, X. Wu, A. N. Garcia, J. R. Jacobson, J. X. - J. Yuan, J. G. N. Garcia, and S. M. Black, "Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 4, pp. L452-L476, 2017 Apr 01. PMID: 27979857
Bauman, J. E., E. Cohen, R. L. Ferris, D. J. Adelstein, D. M. Brizel, J. A. Ridge, B. O'Sullivan, B. A. Burtness, L. H. Butterfield, W. E. Carson, et al., "Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.", Cancer, vol. 123, issue 7, pp. 1259-1271, 2017 Apr 01. PMID: 27906454
Sundaresan, S., C. A. Meininger, A. J. Kang, A. L. Photenhauer, M. M. Hayes, N. Sahoo, J. Grembecka, T. Cierpicki, L. Ding, T. J. Giordano, et al., "Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.", Gastroenterology, vol. 153, issue 6, pp. 1555-1567.e15, 2017 12. PMCID: PMC5705278  PMID: 28859856
Day, S. E., L. A. Garcia, R. L. Coletta, L. E. Campbell, T. R. Benjamin, E. A. De Filippis, J. A. Madura, L. J. Mandarino, L. R. Roust, and D. K. Coletta, "Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery.", Clin Epigenetics, vol. 9, pp. 96, 2017. PMCID: PMC5581422  PMID: 28883895
Toosizadeh, N., C. Berry, C. Bime, B. Najafi, M. Kraft, and J. Mohler, "Assessing upper-extremity motion: An innovative method to quantify functional capacity in patients with chronic obstructive pulmonary disease.", PLoS One, vol. 12, issue 2, pp. e0172766, 2017. PMCID: PMC5325547  PMID: 28235045
Ganley, K. J., P. R. Bosch, J. E. Blair, F. Rischard, and J. N. Galgiani, "Oxygen Consumption Deficits in Patients With Residual Fatigue After Primary Coccidioidomycosis", Open Forum Infectious Diseases, vol. 4, issue 3, 06/2017.