Cancer Biology GIDP Seminar: ‘Structure within Ewing Sarcoma: Things that lay between the lion and the mouse’

The Cancer Biology Graduate Interdisciplinary Program and UArizona Cancer Center presents the following for the Cancer Biology GIDP Seminar Series lecture:

Jacob Schwartz, PhD | Associate professor of pharmacology and chemistry & biochemistry at the University of Arizona College of Medicine – Tucson, as well as the Cancer Biology Graduate Interdisciplinary Program and Neuroscience GIDP at the U of A; associate director, Cancer Research Training and Education Coordination, U of A Cancer Center; and a member of the BIO5 Institute and Graduate Faculty at the U of A.

“Structure within Ewing Sarcoma: Things that lay between the lion and the mouse”

Monday, Feb. 3, 2025 | 9:00 - 10:00 a.m.
UArizona Cancer Center – Kiewit Auditorium (Room 2951A) or
Join Zoom Meeting: https://arizona.zoom.us/j/89130395406 (Password can be found on the flyer below.)

Cancer Biology GIDP Seminar Series
Fall Instructor: Dr. Nam Lee 
Contact: namlee@arizona.ed

About the Presenter

Dr. Schwartz's lab studies transcription regulation by RNA-binding proteins, focusing on disordered proteins whose activity depends on the process of phase separation. His team uses biochemical and cell-based approaches to investigate mechanisms that the closely related proteins FUS, TDP-43, and EWSR1 control gene expression. Using this knowledge, they analyze therapeutic approaches and the mechanism for the EWS-FLI1 fusion protein to hijack EWSR1 activity and drive Ewing Sarcoma, a rare, malignant bone cancer that primarily affects children and young adults and the second most common bone cancer in children. As part of this research, they’ve developed new methods to investigate protein unfolding by chemical conjugation and to isolate cellular condensates for proteomics analysis.

LEARN MORE

Flyer for this lecture:  cancer_biology_gidp_seminar_2.3.25_schwartz_flyer.pdf

Original event listing.

For this and other Biological and Biomedical Seminars on the UArizona Health Sciences Calendar, click here.