SPEAKER: H. Thomas Lee, M.D., Ph.D.
Professor, Department of Anesthesiology
Director of Transplantation Anesthesiology
Vice Chair for Laboratory Research
Department of Anesthesiology
New York Presbyterian Medical Center
College of Physicians and Surgeons of Columbia University, N.Y.
TOPIC: “Mechanism of Remote Organ Injury After Ischemic AKI”
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Dr. Lee's research focuses on the pathomechanisms of perioperative acute kidney injury and translational approaches to attenuate this injury. The laboratory is focusing on the role of ischemic preconditioning, adenosine receptors, sphingosine products, volatile anesthetics and local anesthetics in attenuating acute kidney injury in vivo, as well as in vitro. The models used to induce acute kidney injury in vivo include renal ischemia reperfusion, cecal ligation and puncture induced sepsis and myoglobinuria rabdomyolysis model. Recently, a model of acute kidney injury in the setting of acute liver failure (hepatorenal syndrome) has been developed and multiple treatment modalities to treat this critical syndrome are being investigated. Dr. Lee uses multiple molecular and biochemical approaches, as well as in vivo techniques, to better understand both the injurious and protective signaling pathways involved in the injury.
He is speaking at the University of Arizona as a guest of the UA College of Pharmacy and Dean Rick G. Schnellmann, PhD.
Objectives:
- Why acute kidney injury is so lethal and costly
- Significance of remote organ dysfunction after acute kidney injury
- Mechanisms of remote organ dysfunction after acute kidney injury
An RSVP is requested. Email Liz Mellor, Executive Assistant, UA College of Pharmacy, lmellor@pharmacy.arizona.edu
Roy P. Drachman Hall, 3rd Floor, Room A326
1295 N. Martin
Tucson, AZ 85721
