Saif A. Mashaqi, MD

  • Associate Professor, Medicine - (Clinical Scholar Track)

Saif A. Mashaqi, MD, joined the faculty of the University of Arizona College of Medicine – Tucson in September 2019 as an associate professor of medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, one of 14 divisions in the Department of Medicine which is the largest department at the UA College of Medicine. Previously, he was an assistant and associate professor of medicine at the University of North Dakota School of Medicine and Health Sciences in Grand Forks, N.D., and the medical director of the Sanford Sleep Center in Jamestown, N.D. He has been a fellow member of the American Academy of Sleep Medicine (FAASM) and the American College of Chest Physicians (FCCP). He completed his sleep medicine and critical care fellowships at the Cleveland Clinic in Cleveland, Ohio. He did his internal medicine residency and pulmonary diseases fellowship at Marshall University School of Medicine in Huntington, W.V. Dr. Mashaqi grew up in Amman, Jordan, and earned his MBBS degree in medicine from University of Jordan School of Medicine. He moved to the United States in 2006.

Research Interests: 

- The role of gut microbiota as a mediator of obstructive sleep apnea associated comorbidities (obesity and systemic hypertension).
- The role of gut dysbiosis in circadian rhythm misalignment.
- The impact of sleep disordered breathing and positive airway pressure therapy on hormones and metabolites regulating food intake and energy homeostasis.
- Screening for obstructive sleep apnea.

  • MD: University of Jordan School of Medicine, Amman, Jordan, 2002
Honors and Awards
  • Alpha Omega Alpha Honor Medical Society, 2010
  • Internal Medicine: Marshall University, Huntington, W.V., 2007-09
  • Internal Medicine: Marshall University, Huntington, W.V., 2006-07
  • Critical Care Medicine: Cleveland Clinic, Cleveland, Ohio, 2012-13
  • Sleep Medicine: Cleveland Clinic, Cleveland, Ohio, 2011-12
  • Pulmonary Disease: Marshall University, Huntington, W.V., 2009-11
Board Certifications
  • ABIM – Critical Care, 2016
  • ABIM – Sleep Medicine, 2013
  • ABIM – Pulmonary, 2011
  • American Board of Internal Medicine, 2009

Select Publications


Berryhill, S., C. J. Morton, A. Dean, A. Berryhill, N. Provencio-Dean, S. I. Patel, L. Estep, D. Combs, S. Mashaqi, L. B. Gerald, et al., "Effect of wearables on sleep in healthy individuals: a randomized crossover trial and validation study.", J Clin Sleep Med, vol. 16, issue 5, pp. 775-783, 2020 05 15. PMID: 32043961
Combs, D., C-H. Hsu, O. Bailey, S. I. Patel, S. Mashaqi, L. Estep, N. Provencio-Dean, S. Lopez, and S. Parthasarathy, "Differences in sleep timing and related effects between African Americans and non-Hispanic Whites.", J Clin Sleep Med, 2020 Dec 31. PMID: 33382030
Mashaqi, S., H. M. Mansour, H. Alameddin, D. Combs, S. Patel, L. Estep, and S. Parthasarathy, "Matrix metalloproteinase-9 as a messenger in the crosstalk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review.", J Clin Sleep Med, 2020 Oct 27. PMID: 33108267


Mashaqi, S., and S. M Badr, "The Impact of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Metabolic Peptides Regulating Appetite, Food Intake, Energy Homeostasis, and Systemic Inflammation: A Literature Review.", J Clin Sleep Med, vol. 15, issue 7, pp. 1037-1050, 2019 Jul 15. PMCID: PMC6622519  PMID: 31383242
Mashaqi, S., and D. Gozal, "Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?", J Clin Sleep Med, 2019 Sep 06. PMID: 31490117