Translational and Regenerative Medicine

Cancer Pathobiology, Tumorigenesis, and Cancer Prevention and Treatment

The ability of cancers to develop is attributed to a set of hallmarks: unlimited growth, resistance to cell death (apoptosis), a blood supply (angiogenesis), evasion of the body’s immune system, and ability to leave the primary tumor site and grow in other organs (invasion and metastasis). Our scientists continue to work to understand these hallmarks of cancer to further clarify mechanisms contributing to this complex disease and to develop novel therapeutic remedies.

Coronary and Pulmonary Vascular Endothelial Dysfunction in Diabetes

Cardiopulmonary and vascular complications associated with diabetes are major contributors to mortality of patients with diabetes. Vascular endothelial cells play a critical role in vascular function, as they are involved in regulation of vascular tone, formation of new vessels, and serving as an anticoagulant barrier between blood and the vascular wall. Many cardiovascular diseases result in endothelial cell damage and subsequent vascular complications.

Lung Vascular Pathobiology and Pulmonary Hypertension

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that predominantly affects women. PAH constitutes a heterogeneous group of clinical disorders sharing similar pathogenic mechanisms and categorized as idiopathic PAH, heritable PAH, associated PAH, persistent pulmonary hypertension of the newborn (PPHN), and pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH).

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