General Internal Medicine, Geriatrics and Palliative Medicine

Metabolic Networks as Functional Biomarkers of Parkinson’s Disease

Brain imaging has been used extensively to identify and validate disease-specific functional networks as biomarkers in neurodegenerative disorders. Although disease networks are highly reproducible across patient populations, it is not known whether these topographies reflect pathological connectivity patterns that worsen with advancing disease, or beneficial adaptations that may be promoted by treatment.

Adaptive and pathological connectivity responses in Parkinson’s disease brain networks

Brain imaging has been used extensively to identify and validate disease-specific functional networks as biomarkers in neurodegenerative disorders. Although disease networks are highly reproducible across patient populations, it is not known whether these topographies reflect pathological connectivity patterns that worsen with advancing disease, or beneficial adaptations that may be promoted by treatment.

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