The following published papers illustrate the latest investigative endeavors of faculty and research staff in the University of Arizona Department of Medicine and its 14 divisions. Click the PubMed links to read on about how they're setting the pace for the future of health care and precision medicine solutions to improve patient lives in Arizona and beyond.


Shubitz, L. F., D. A. Powell, H. T. Trinh, L. M Lewis, M. J. Orbach, J. A. Frelinger, and J. N. Galgiani, "Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.", Vaccine, 2018 Apr 30. PMID: 29724507
Patel, S. I., P. Gay, T. I. Morgenthaler, E. J. Olson, F. E. Shamoun, R. Kashyap, D. Herold, S. McNamara, and B. Selim, "Practical Implementation of a Single-Night Split-Titration Protocol With BPAP-ST and AVAPS in Patients With Neuromuscular Disease.", J Clin Sleep Med, vol. 14, issue 12, pp. 2031-2035, 2018 12 15. PMCID: PMC6287715  PMID: 30518448
Beatty, N. L., C. M. Perez-Velez, H. D. Yaglom, S. Carson, E. Liu, Z. I. Khalpey, S. A. Klotz, and S. P. Elliott, "Evidence of Likely Autochthonous Transmission of Chagas Disease in Arizona.", Am J Trop Med Hyg, vol. 99, issue 6, pp. 1534-1536, 2018 12. PMCID: PMC6283477  PMID: 30277208
Roman, J., G. Viegi, M. Schenker, V. D. Ojeda, E. J. Pérez-Stable, B. Nemery, I. Annesi-Maesano, S. R. Patel, S. La Grutta, F. Holguin, et al., "Research Needs on Respiratory Health in Migrant and Refugee Populations. An Official American Thoracic Society and European Respiratory Society Workshop Report.", Ann Am Thorac Soc, vol. 15, issue 11, pp. 1247-1255, 2018 11. PMID: 30382778
Lindberg, C. M., K. Srinivasan, B. Gilligan, J. Razjouyan, H. Lee, B. Najafi, K. J. Canada, M. R. Mehl, F. Currim, S. Ram, et al., "Effects of office workstation type on physical activity and stress.", Occup Environ Med, vol. 75, issue 10, pp. 689-695, 2018 10. PMCID: PMC6166591  PMID: 30126872
Wang, Z., R. Ocadiz-Ruiz, S. Sundaresan, L. Ding, M. Hayes, N. Sahoo, H. Xu, and J. L. Merchant, "Isolation of Enteric Glial Cells from the Submucosa and Lamina Propria of the Adult Mouse.", J Vis Exp, issue 138, 2018 08 15. PMCID: PMC6126789  PMID: 30175991
Russell, K., K. Herrick, H. Venkat, S. Brady, K. Komatsu, K. Goodin, V. Berisha, R. Sunenshine, C. Perez-Velez, S. Elliott, et al., "Utility of state-level influenza disease burden and severity estimates to investigate an apparent increase in reported severe cases of influenza A(H1N1) pdm09 - Arizona, 2015-2016.", Epidemiol Infect, vol. 146, issue 11, pp. 1359-1365, 2018 08. PMID: 29898797
Breathett, K., L. A. Allen, L. Helmkamp, K. Colborn, S. L. Daugherty, I. V. Blair, J. Jones, P. Khazanie, S. Mazimba, M. McEwen, et al., "Temporal Trends in Contemporary Use of Ventricular Assist Devices by Race and Ethnicity.", Circ Heart Fail, vol. 11, issue 8, pp. e005008, 2018 08. PMCID: PMC6086596  PMID: 30021796
Bime, C., N. Pouladi, S. Sammani, K. Batai, N. Casanova, T. Zhou, C. L. Kempf, X. Sun, S. M. Camp, T. Wang, et al., "Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.", Am J Respir Crit Care Med, vol. 197, issue 11, pp. 1421-1432, 2018 06 01. PMCID: PMC6005557  PMID: 29425463
Willis, W. T., D. Miranda-Grandjean, J. Hudgens, E. A. Willis, J. Finlayson, E. A. De Filippis, Z. R Bustos, P. R. Langlais, C. Mielke, and L. J. Mandarino, "Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of lysine acetylation.", Arch Biochem Biophys, vol. 647, pp. 93-103, 2018 06 01. PMID: 29653079
Almodovar, S., J. Swanson, L. D. Giavedoni, S. Kanthaswamy, C. S. Long, N. F. Voelkel, M. G. Edwards, J. M. Folkvord, E. Connick, S. V. Westmoreland, et al., "Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques.", Viral Immunol, vol. 31, issue 3, pp. 206-222, 2018 04. PMCID: PMC5909115  PMID: 29256819
Webb, G. M., S. Li, G. Mwakalundwa, J. M. Folkvord, J. M. Greene, J. S. Reed, J. J. Stanton, A. W. Legasse, T. Hobbs, L. D. Martin, et al., "The human IL-15 superagonist ALT-803 directs SIV-specific CD8 T cells into B-cell follicles.", Blood Adv, vol. 2, issue 2, pp. 76-84, 2018 01 23. PMCID: PMC5787870  PMID: 29365313
Javle, M., M. Lowery, R. T. Shroff, K. Heinz Weiss, C. Springfeld, M. J. Borad, R. K. Ramanathan, L. Goyal, S. Sadeghi, T. Macarulla, et al., "Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma.", J Clin Oncol, vol. 36, issue 3, pp. 276-282, 2018 01 20. PMCID: PMC6075847  PMID: 29182496
Shroff, R. T., M. Yarchoan, A. O'Connor, D. Gallagher, M. L. Zahurak, G. Rosner, C. Ohaji, S. Sartorius-Mergenthaler, R. Parkinson, V. Subbiah, et al., "The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma.", Br J Cancer, vol. 118, issue 2, pp. e2, 2018 01. PMCID: PMC5785753  PMID: 29315294
Robbins, R., A. Seixas, G. Jean-Louis, S. Parthasarathy, D. M. Rapoport, G. Ogedegbe, and J. A. Ladapo, "National patterns of physician management of sleep apnea and treatment among patients with hypertension.", PLoS One, vol. 13, issue 5, pp. e0196981, 2018. PMCID: PMC5965818  PMID: 29791455
Merchant, J. L., "Parietal Cell Death by Cytokines.", Cell Mol Gastroenterol Hepatol, vol. 5, issue 4, pp. 636-637, 2018. PMCID: PMC5924744  PMID: 29713663
Foote, F. O., H. Benson, A. Berger, B. Berman, J. DeLeo, P. A. Deuster, D. J. Lary, M. N. Silverman, and E. M. Sternberg, "Advanced Metrics for Assessing Holistic Care: The "Epidaurus 2" Project.", Glob Adv Health Med, vol. 7, pp. 2164957X18755981, 2018. PMCID: PMC5824899  PMID: 29497586
Razumilava, N., D. L. Gumucio, L. C. Samuelson, Y. M. Shah, A. Nusrat, and J. L. Merchant, "Indian Hedgehog Suppresses Intestinal Inflammation.", Cell Mol Gastroenterol Hepatol, vol. 5, issue 1, pp. 63-64, 2018. PMCID: PMC5736880  PMID: 29276751
Bronnimann, M. P., P. J. Skinner, and E. Connick, "The B-Cell Follicle in HIV Infection: Barrier to a Cure.", Front Immunol, vol. 9, pp. 20, 2018. PMCID: PMC5788973  PMID: 29422894
Engineer, A., E. M. Sternberg, and B. Najafi, "Designing Interiors to Mitigate Physical and Cognitive Deficits Related to Aging and to Promote Longevity in Older Adults: A Review.", Gerontology, vol. 64, issue 6, pp. 612-622, 2018. PMID: 30130764


Herbst, K. L., C. Ussery, and A. Eekema, "Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema.", Horm Mol Biol Clin Investig, vol. 33, issue 2, 2017 Sep 20. PMID: 28930626
Kruse, R., J. Krantz, N. Barker, R. L. Coletta, R. Rafikov, M. Luo, K. Højlund, L. J. Mandarino, and P. R. Langlais, "Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.", Mol Cell Proteomics, vol. 16, issue 10, pp. 1718-1735, 2017 Oct. PMCID: PMC5629260  PMID: 28550165
Indik, J. H., K. K. Patton, M. Beardsall, C. A. Chen-Scarabelli, M. I. Cohen, T-M. L. Dickfeld, D. E. Haines, R. H. Helm, K. Krishnan, J. Cosedis Nielsen, et al., "HRS Clinical Document Development Methodology Manual and Policies: Executive summary.", Heart Rhythm, vol. 14, issue 10, pp. e495-e500, 2017 Oct. PMID: 28965612
Tracy, C. M., G. H. Crossley, J. T Bunch, G. V. Chow, A. Leiserowitz, J. H. Indik, F. Kusumoto, L. A. Mendes, T. M. Munger, S. Murali, et al., "2017 ACC/HRS Lifelong Learning Statement for Clinical Cardiac Electrophysiology Specialists: A Report of the ACC Competency Management Committee.", J Am Coll Cardiol, 2017 Nov 15. PMID: 29191467
Ocadiz-Ruiz, R., A. L. Photenhauer, M. M. Hayes, L. Ding, E. R. Fearon, and J. L. Merchant, "ZBP-89 function in colonic stem cells and during butyrate-induced senescence.", Oncotarget, vol. 8, issue 55, pp. 94330-94344, 2017 Nov 07. PMCID: PMC5706877  PMID: 29212231
Vaughn, A. R., P. Tannhauser, R. K. Sivamani, and V. Y. Shi, "Mother Nature in Eczema: Maternal Factors Influencing Atopic Dermatitis.", Pediatr Dermatol, vol. 34, issue 3, pp. 240-246, 2017 May. PMID: 28523877
Ding, Q., I. Subramanian, T. R. Luckhardt, P. Che, M. Waghray, X. Zhao, N. Bone, A. R. Kurundkar, L. Hecker, M. Hu, et al., "Focal Adhesion Kinase Signaling Determines the Fate of Lung Epithelial Cells in Response to TGF-β.", Am J Physiol Lung Cell Mol Physiol, pp. ajplung.00121.2016, 2017 Mar 30. PMID: 28360109
Bauman, J. E., U. Duvvuri, W. E. Gooding, T. J. Rath, N. D. Gross, J. Song, A. Jimeno, W. G. Yarbrough, F. M. Johnson, L. Wang, et al., "Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer.", JCI Insight, vol. 2, issue 6, pp. e90449, 2017 Mar 23. PMCID: PMC5358497  PMID: 28352657
Palumbo, S., Y-J. Shin, K. Ahmad, A. A. Desai, H. Quijada, M. Mohamed, A. Knox, S. Sammani, B. A. Colson, T. Wang, et al., "Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L297-L308, 2017 Mar 01. PMID: 28062482
Song, S., R. J. Ayon, A. Yamamura, H. Yamamura, S. Dash, A. Babicheva, H. Tang, X. Sun, A. G. Cordery, Z. Khalpey, et al., "Capsaicin-induced Ca(2+) signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.", Am J Physiol Lung Cell Mol Physiol, vol. 312, issue 3, pp. L309-L325, 2017 Mar 01. PMID: 27979859
Katial, R. K., G. W. Bensch, W. W. Busse, B. E. Chipps, J. L. Denson, A. N. Gerber, J. S. Jacobs, M. Kraft, R. J. Martin, P. Nair, et al., "Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies.", J Allergy Clin Immunol Pract, vol. 5, issue 2S, pp. S1-S14, 2017 Mar - Apr. PMID: 28143691
Addison, K. J., J. Morse, A. Robichaud, M. O. Daines, and J. G. Ledford, "A Novel in vivo System to Test Bronchodilators.", J Infect Pulm Dis, vol. 3, issue 1, 2017 Mar. PMID: 28367537
Zhang, Y., L. Wang, Y. Zi, L. Zhang, Y. Guo, and Y. Huang, "Oridonin effectively reverses the drug resistance of cisplatin involving induction of cell apoptosis and inhibition of MMP expression in human acute myeloid leukemia cells.", Saudi J Biol Sci, vol. 24, issue 3, pp. 678-686, 2017 Mar. PMCID: PMC5372424  PMID: 28386196
Joseph, B., T. Orouji Jokar, A. Hassan, A. Azim, M. Jane Mohler, N. Kulvatunyou, S. Siddiqi, H. Phelan, M. Fain, and P. Rhee, "Redefining the association between old age and poor outcomes after trauma: The impact of frailty syndrome.", J Trauma Acute Care Surg, vol. 82, issue 3, pp. 575-581, 2017 Mar. PMID: 28225741
Tager, D., A. Hatch, J. Segar, B. Roller, M. Al Mohajer, and T. T. Zangeneh, "Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia.", Med Mycol Case Rep, vol. 16, pp. 8-11, 2017 Jun. PMCID: PMC5374848  PMID: 28386527
Trusler, A. R., A. K. Clark, R. K. Sivamani, and V. Y. Shi, "The Endocannabinoid System and Its Role in Eczematous Dermatoses.", Dermatitis, vol. 28, issue 1, pp. 22-32, 2017 Jan/Feb. PMID: 28098721
Tey, K. Rou, A. Aggarwal, and B. Banerjee, "Migrating coil.", BMJ Case Rep, vol. 2017, 2017 Jan 27. PMID: 28130285
Oesterle, A., U. Laufs, and J. K. Liao, "Pleiotropic Effects of Statins on the Cardiovascular System.", Circ Res, vol. 120, issue 1, pp. 229-243, 2017 Jan 06. PMCID: PMC5467317  PMID: 28057795
Kumar, iv, S., X. Sun, S. Kumar Noonepalle, Q. Lu, E. Zemskov, T. Wang, S. Aggarwal, C. Gross, S. Sharma, A. A. Desai, et al., "Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.", Free Radic Biol Med, vol. 102, pp. 217-228, 2017 Jan. PMID: 27838434
Chen, J., J. R. Sysol, S. Singla, S. Zhao, A. Yamamura, D. Valdez-Jasso, T. Abbasi, K. M. Shioura, S. Sahni, V. Reddy, et al., "Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension.", Circulation, 2017 Feb 15. PMID: 28202489
Huang, Y., S-F. Ma, M. S. Espindola, R. Vij, J. M. Oldham, G. B. Huffnagle, J. R. Erb-Downward, K. R. Flaherty, B. B. Moore, E. S. White, et al., "Microbes Associate with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.", Am J Respir Crit Care Med, 2017 Feb 03. PMID: 28157391
Su, X., X. Qiao, J. Li, L. Gao, C. Wang, and L. Wang, "Papulonodular mucinosis, Guillain-Barré syndrome and nephrotic syndrome in a patient with systemic lupus erythematosus: a case report.", BMC Nephrol, vol. 18, issue 1, pp. 43, 2017 Feb 01. PMCID: PMC5286654  PMID: 28143420
Kartan, S., V. Y. Shi, A. K. Clark, and L. S. Chan, "Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment.", Am J Clin Dermatol, vol. 18, issue 1, pp. 105-126, 2017 Feb. PMID: 27878477
Infante, J. R., A. Patnaik, C. F. Verschraegen, A. J. Olszanski, M. Shaheen, H. A. Burris, A. W. Tolcher, K. P. Papadopoulos, M. Beeram, S. M. Hynes, et al., "Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer.", Cancer Chemother Pharmacol, vol. 79, issue 2, pp. 315-326, 2017 Feb. PMID: 28097385
Odio, C. D., B. E. Marciano, J. N. Galgiani, and S. M. Holland, "Risk Factors for Disseminated Coccidioidomycosis, United States.", Emerg Infect Dis, vol. 23, issue 2, 2017 Feb. PMCID: PMC5324825  PMID: 28098554
Ebner, L., M. He, R. S. Virgincar, T. Heacock, S. S. Kaushik, M. S. Freemann, P. H McAdams, M. Kraft, and B. Driehuys, "Hyperpolarized 129Xenon Magnetic Resonance Imaging to Quantify Regional Ventilation Differences in Mild to Moderate Asthma: A Prospective Comparison Between Semiautomated Ventilation Defect Percentage Calculation and Pulmonary Function Tests.", Invest Radiol, vol. 52, issue 2, pp. 120-127, 2017 Feb. PMID: 27662575
Li, Q., G. A Schissler, V. Gardeux, J. Berghout, I. Achour, C. Kenost, H. Li, H. Helen Zhang, and Y. A. Lussier, "kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects.", J Biomed Inform, vol. 66, pp. 32-41, 2017 Feb. PMCID: PMC5316373  PMID: 28007582
Donovan, F. M., T. T. Zangeneh, J. Malo, and J. N. Galgiani, "Top Questions in the Diagnosis and Treatment of Coccidioidomycosis.", Open Forum Infect Dis, vol. 4, issue 4, pp. ofx197, 2017 Fall. PMCID: PMC5903411  PMID: 29670928
Mashaqi, S., J. Hennessy, M. Eaton, and J. Erickson, "Obstructive Sleep Apnea in a Patient with Cornelia de Lange Syndrome.", Cureus, vol. 9, issue 12, pp. e1993, 2017 Dec 28. PMCID: PMC5832399  PMID: 29507843
Derkac, W. M., J. R. Finkelmeier, D. J. Horgan, and M. D. Hutchinson, "Diagnostic yield of asymptomatic arrhythmias detected by mobile cardiac outpatient telemetry and autotrigger looping event cardiac monitors.", J Cardiovasc Electrophysiol, vol. 28, issue 12, pp. 1475-1478, 2017 Dec. PMID: 28940881