The following published papers illustrate the latest investigative endeavors of faculty and research staff in the University of Arizona Department of Medicine and its 14 divisions. Click the PubMed links to read on about how they're setting the pace for the future of health care and precision medicine solutions to improve patient lives in Arizona and beyond.


Carr, T. F., and M. Kraft, "Chronic Infection and Severe Asthma.", Immunol Allergy Clin North Am, vol. 36, issue 3, pp. 483-502, 2016 Aug. PMID: 27401621
Bojang, P., and K. S. Ramos, "Analysis of LINE-1 Retrotransposition at the Single Nucleus Level.", J Vis Exp, issue 110, 2016 Apr 23. PMID: 27167780
Page, R. L., J. A. Joglar, M. A. Caldwell, H. Calkins, J. B. Conti, B. J. Deal, N. A. Mark Estes, M. E. Field, Z. D. Goldberger, S. C. Hammill, et al., "2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.", J Am Coll Cardiol, vol. 67, issue 13, pp. e27-e115, 2016 Apr 05. PMID: 26409259
Hedberg, M. L., G. Goh, S. I. Chiosea, J. E. Bauman, M. L. Freilino, Y. Zeng, L. Wang, B. B. Diergaarde, W. E. Gooding, V. W Y Lui, et al., "Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.", J Clin Invest, vol. 126, issue 4, pp. 1606, 2016 Apr 01. PMCID: PMC4811141  PMID: 27035818
Nikolich-Žugich, J., D. P. Goldman, P. R. Cohen, D. Cortese, L. Fontana, B. K. Kennedy, J. M Mohler, J. S Olshansky, T. Perls, D. Perry, et al., "Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.", J Gerontol A Biol Sci Med Sci, vol. 71, issue 4, pp. 435-44, 2016 Apr. PMCID: PMC5014189  PMID: 26419976
Knowles, L. M., P. Skeath, M. Jia, B. Najafi, J. Thayer, and E. M. Sternberg, "New and Future Directions in Integrative Medicine Research Methods with a Focus on Aging Populations: A Review.", Gerontology, vol. 62, issue 4, pp. 467-76, 2016. PMID: 26545038
Smith, K. A., R. J. Ayon, H. Tang, A. Makino, and J. X. - J. Yuan, "Calcium-Sensing Receptor Regulates Cytosolic [Ca (2+) ] and Plays a Major Role in the Development of Pulmonary Hypertension.", Front Physiol, vol. 7, pp. 517, 2016. PMCID: PMC5095111  PMID: 27867361
Tran, K. A., M. Y. Cheng, A. Mitra, H. Ogawa, V. Y. Shi, L. P. Olney, A. M. Kloxin, and E. Maverakis, "MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy.", Drug Des Devel Ther, vol. 10, pp. 43-52, 2016. PMCID: PMC4694671  PMID: 26730180
Li, H., I. Achour, L. Bastarache, J. Berghout, V. Gardeux, J. Li, Y. Lee, L. Pesce, X. Yang, K. S. Ramos, et al., "Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.", NPJ Genom Med, vol. 1, 2016. PMCID: PMC4966659  PMID: 27482468
Miles, B., S. M. Miller, and E. Connick, "CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection.", Front Immunol, vol. 7, pp. 659, 2016. PMCID: PMC5187376  PMID: 28082992
Reyes-Reyes, E. M., I. N. Ramos, M. A. Tavera-Garcia, and K. S. Ramos, "The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-β1 signaling: implications in hepatocellular carcinogenesis.", Am J Cancer Res, vol. 6, issue 5, pp. 1066-77, 2016. PMCID: PMC4889720  PMID: 27293999


Wack, E. E., N. M. Ampel, R. H. Sunenshine, and J. N. Galgiani, "The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis.", Clin Infect Dis, vol. 61, issue 5, pp. 787-91, 2015 Sep 01. PMID: 25979308
Dunn, R. M., E. Lehman, V. M. Chinchilli, R. J. Martin, H. A. Boushey, E. Israel, M. Kraft, S. C. Lazarus, R. F. Lemanske, N. L. Lugogo, et al., "Impact of Age and Sex on Response to Asthma Therapy.", Am J Respir Crit Care Med, vol. 192, issue 5, pp. 551-8, 2015 Sep 01. PMCID: PMC4595693  PMID: 26068329
Frankwich, K. A., J. Egnatios, M. L. Kenyon, T. R. Rutledge, P. S. Liao, S. Gupta, K. L. Herbst, and A. Zarrinpar, "Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial.", Clin Gastroenterol Hepatol, vol. 13, issue 9, pp. 1625-1632.e1, 2015 Sep. PMCID: PMC4546861  PMID: 25769412
Mohler, J., B. Najafi, M. Fain, and K. S. Ramos, "Precision Medicine: A Wider Definition.", J Am Geriatr Soc, vol. 63, issue 9, pp. 1971-2, 2015 Sep. PMID: 26390003
Qian, Z., T. Zhou, C. I. Gurguis, X. Xu, Q. Wen, J. Lv, F. Fang, L. Hecker, A. E. Cress, V. Natarajan, et al., "Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival.", Sci Rep, vol. 5, pp. 16889, 2015 Nov 24. PMCID: PMC4657037  PMID: 26596768
Huang, Y., S-F. Ma, R. Vij, J. M. Oldham, J. Herazo-Maya, S. M. Broderick, M. E. Strek, S. R. White, K. D Hogarth, N. K. Sandbo, et al., "A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis.", BMC Pulm Med, vol. 15, pp. 147, 2015 Nov 21. PMCID: PMC4654815  PMID: 26589497
Qiao, X., L. Wang, Y. Wang, N. Zhao, R. Zhang, W. Han, and Z. Peng, "Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction.", Nephrology (Carlton), vol. 20, issue 11, pp. 820-31, 2015 Nov. PMID: 26014968
Postow, M. A., J. Chesney, A. C. Pavlick, C. Robert, K. Grossmann, D. McDermott, G. P. Linette, N. Meyer, J. K. Giguere, S. S. Agarwala, et al., "Nivolumab and ipilimumab versus ipilimumab in untreated melanoma.", N Engl J Med, vol. 372, issue 21, pp. 2006-17, 2015 May 21. PMID: 25891304
Boyd, A. D., J. John Li, C. Kenost, B. Joese, Y. Min Yang, O. A. Kalagidis, I. Zenku, D. Saner, N. Bahroos, and Y. A. Lussier, "Metrics and tools for consistent cohort discovery and financial analyses post-transition to ICD-10-CM.", J Am Med Inform Assoc, vol. 22, issue 3, pp. 730-7, 2015 May. PMCID: PMC4457110  PMID: 25681260
Martinez, G., and K. Knox, "Mentor Match for physician-faculty: the search for 'Dr Right'.", Med Educ, vol. 49, issue 5, pp. 533-4, 2015 May. PMID: 25924153
A Schissler, G., V. Gardeux, Q. Li, I. Achour, H. Li, W. W. Piegorsch, and Y. A. Lussier, "Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival.", Bioinformatics, vol. 31, issue 12, pp. i293-302, 2015 Jun 15. PMCID: PMC4765863  PMID: 26072495
Postma, D. S., C. Brightling, L. Fabbri, T. van der Molen, G. Nicolini, A. Papi, K. F. Rabe, S. Siddiqui, D. Singh, M. van den Berge, et al., "Unmet needs for the assessment of small airways dysfunction in asthma: introduction to the ATLANTIS study.", Eur Respir J, vol. 45, issue 6, pp. 1534-8, 2015 Jun. PMID: 26028618
Metcalf, T. U., R. A. Cubas, K. Ghneim, M. J. Cartwright, J. Van Grevenynghe, J. M. Richner, D. P. Olagnier, P. A. Wilkinson, M. J. Cameron, B. S. Park, et al., "Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.", Aging Cell, vol. 14, issue 3, pp. 421-32, 2015 Jun. PMCID: PMC4406671  PMID: 25728020
Amin, A. Dipak, S. S. Rajan, W. S. Liang, P. Pongtornpipat, M. J. Groysman, E. O. Tapia, T. L. Peters, L. Cuyugan, J. Adkins, L. M. Rimsza, et al., "Evidence Suggesting That Discontinuous Dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors.", Cancer Res, vol. 75, issue 14, pp. 2916-27, 2015 Jul 15. PMCID: PMC4506255  PMID: 26018086
Carr, T. F., and M. Kraft, "Update in Asthma 2014.", Am J Respir Crit Care Med, vol. 192, issue 2, pp. 157-63, 2015 Jul 15. PMID: 26177171
Katkam, R., B. Banerjee, C. Yu Huang, X. Zhu, L. Ocampo, J-L. Kincade, and R. Liang, "Compact dual-view endoscope without field obscuration.", J Biomed Opt, vol. 20, issue 7, pp. 76007, 2015 Jul. PMID: 26178408
Boyd, A. D., Y. Min Yang, J. Li, C. Kenost, M. D. Burton, B. Becker, and Y. A. Lussier, "Challenges and remediation for Patient Safety Indicators in the transition to ICD-10-CM.", J Am Med Inform Assoc, vol. 22, issue 1, pp. 19-28, 2015 Jan. PMCID: PMC4433358  PMID: 25186492
Chatelain, S., R. A. Comp, R. R Grace, and A. M. Sabbath, "Cardiomyopathy induced by pulmonary sequestration in a 50-year-old man.", Tex Heart Inst J, vol. 42, issue 1, pp. 63-5, 2015 Feb. PMCID: PMC4378049  PMID: 25873803
Li, H., N. Pouladi, I. Achour, V. Gardeux, J. Li, Q. Li, H. Helen Zhang, F. D. Martinez, J. G. N. 'Skip' Garcia, and Y. A. Lussier, "eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs.", J Biomed Inform, vol. 58, pp. 226-34, 2015 Dec. PMCID: PMC4684766  PMID: 26524128
Shubitz, L. F., H. T. Trinh, J. N. Galgiani, M. L. Lewis, A. W. Fothergill, N. P. Wiederhold, B. M. Barker, E. R. G. Lewis, A. L. Doyle, W. J. Hoekstra, et al., "Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models.", Antimicrob Agents Chemother, vol. 59, issue 12, pp. 7249-54, 2015 Dec. PMCID: PMC4649211  PMID: 26369964
Ampel, N. M., L. A. Nesbit, C. T. Nguyen, S. Chavez, K. S. Knox, S. M. Johnson, and D. Pappagianis, "Cytokine Profiles from Antigen-Stimulated Whole-Blood Samples among Patients with Pulmonary or Nonmeningeal Disseminated Coccidioidomycosis.", Clin Vaccine Immunol, vol. 22, issue 8, pp. 917-22, 2015 Aug. PMCID: PMC4519718  PMID: 26041038
Liu, Y., R. A. Pleasants, J. B. Croft, A. G. Wheaton, K. Heidari, A. M. Malarcher, J. A. Ohar, M. Kraft, D. M. Mannino, and C. Strange, "Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history.", Int J Chron Obstruct Pulmon Dis, vol. 10, pp. 1409-16, 2015. PMCID: PMC4516194  PMID: 26229460
Qiao, X., L. Wang, C. Wang, L. Gao, S. Yao, L. Wu, and X. Zhang, "IgG4-related tubulointerstitial nephritis associated with only lymphadenopathy and without elevated serum IgG4 or renal imaging abnormalities: a case report and literature review.", Int J Clin Exp Med, vol. 8, issue 10, pp. 19548-55, 2015. PMCID: PMC4694508  PMID: 26770608
Tan, Z., L. Wang, C. Wang, L. Gao, and Y. Yang, "Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report.", Int J Clin Exp Med, vol. 8, issue 2, pp. 2966-73, 2015. PMCID: PMC4402912  PMID: 25932265
Pleasants, R. A., K. Heidari, A. G. Wheaton, J. A. Ohar, C. Strange, J. B. Croft, W. Liao, D. M. Mannino, and M. Kraft, "Targeting Persons With or At High Risk for Chronic Obstructive Pulmonary Disease by State-based Surveillance.", COPD, vol. 12, issue 6, pp. 680-9, 2015. PMCID: PMC4674427  PMID: 26367193
Martirosyan, N. L., J. M. Skoch, O. Zaninovich, C. Zoccali, J. N. Galgiani, and A. A. Baaj, "A paradigm for the evaluation and management of spinal coccidioidomycosis.", Surg Neurol Int, vol. 6, pp. 107, 2015. PMCID: PMC4483783  PMID: 26167359
Rodriguez-Pla, A., and P. A. Monach, "Primary angiitis of the central nervous system in adults and children.", Rheum Dis Clin North Am, vol. 41, issue 1, pp. 47-62, viii, 2015. PMID: 25399939
Carr, TF., and GF. Martinez, "Credibility and (dis)use of feedback to inform teaching : a qualitative case study of physician-faculty perspectives", Southwest J Pulm Crit Care, vol. 10, issue 6, 06/2015.
Spear-Ellinwood, KC., TG. Pritchard, and GF. Martinez, "Establishing Expectations for Teaching: Interns' Perspectives on Good Teaching, Whether They Think They Have What it Takes or Feel Prepared", American Association of Medical Colleges, Western Region Group on Educational Affairs (AAMC-WGEA), San Diego, Calif., 04/2015.


Ketterer, B., C. Self, GF. Martinez, J. Gabbard, and E. Lee, "Advanced Directive Use in Internal Medicine Residency Clinics: A Retrospective Review", Annual Scientific Meeting of the American Geriatrics Society, Orlando, Fla., May 2014.
Wertheimer, A. M., M. S. Bennett, B. Park, J. L. Uhrlaub, C. Martinez, V. Pulko, N. L. Currier, D. Nikolich-Žugich, J. Kaye, and J. Nikolich-Žugich, "Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.", J Immunol, vol. 192, issue 5, pp. 2143-55, 2014 Mar 01. PMCID: PMC3989163  PMID: 24501199
Rodriguez-Pla, A., P. Patel, H. T. Maecker, J. Rossello-Urgell, N. Baldwin, L. Bennett, V. Cantrell, J. Baisch, M. Punaro, A. Gotte, et al., "IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes.", J Immunol, vol. 192, issue 12, pp. 5586-98, 2014 Jun 15. PMCID: PMC5467885  PMID: 24829414
M Mohler, J., M. J. Fain, A. M. Wertheimer, B. Najafi, and J. Nikolich-Žugich, "The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals.", Exp Gerontol, vol. 54, pp. 6-13, 2014 Jun. PMID: 24503059
Shanmugam, I., M. Abbas, F. Ayoub, S. Mirabal, M. Bsaili, E. K. Caulder, D. M. Weinstock, A. E. Tomkinson, R. Hromas, and M. Shaheen, "Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.", J Biol Chem, vol. 289, issue 33, pp. 22739-48, 2014 Aug 15. PMCID: PMC4132780  PMID: 24923443
Navalkar, K. Arun, S. Albert Johnston, N. Woodbury, J. N. Galgiani, M. D Magee, Z. Chicacz, and P. Stafford, "Application of immunosignatures for diagnosis of valley fever.", Clin Vaccine Immunol, vol. 21, issue 8, pp. 1169-77, 2014 Aug. PMCID: PMC4135907  PMID: 24964807
Hecker, L., N. J. Logsdon, D. Kurundkar, A. Kurundkar, K. Bernard, T. Hock, E. Meldrum, Y. Y. Sanders, and V. J. Thannickal, "Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance.", Sci Transl Med, vol. 6, issue 231, pp. 231ra47, 2014 Apr 09. PMCID: PMC4545252  PMID: 24718857
Ross, E., S. E. Robinson, C. Amato, C. McMillan, J. Westcott, T. Wolf, and W. A. Robinson, "Therapeutic monoclonal antibodies in human breast milk: a case study.", Melanoma Res, vol. 24, issue 2, pp. 177-80, 2014 Apr. PMID: 24476799
Murakami, T., B. Banerjee, and N. Ozden, "Novel use of a self-expanding metal stent for an esophageal stricture after radiofrequency ablation treatment of Barrett's esophagus.", Endoscopy, vol. 46 Suppl 1 UCTN, pp. E269-70, 2014. PMID: 24906095
Lee, Y. Ji, A. D. Boyd, J. John Li, V. Gardeux, C. Kenost, D. Saner, H. Li, I. Abraham, J. A. Krishnan, and Y. A. Lussier, "COPD Hospitalization Risk Increased with Distinct Patterns of Multiple Systems Comorbidities Unveiled by Network Modeling.", AMIA Annu Symp Proc, vol. 2014, pp. 855-64, 2014. PMCID: PMC4419951  PMID: 25954392